Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCRArticle Published on 2022-11-042022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] addition affected amplification analyzed approach Blood carried COVID-19 pandemic Critical Ct value detect detection diagnostic diagnostic capabilities digital PCR Dilution droplet False negative Health hospital Infectious disease inhibitors invasive Laboratory less limitation Nasopharyngeal samples parameter PCR platform pool positive sample reagent reagents reduce reducing resources resulting risk Saliva SARS-CoV-2 sensitivity the SARS-CoV-2 virus load was performed [DOI] 10.1371/journal.pone.0271860 PMC 바로가기
Pandemic driven innovation: A pilot evaluation of an alternative respiratory pathogen collection deviceArticle Published on 2022-11-012022-11-16 Journal: The American journal of emergency medicine [Category] SARS, 유전자 메커니즘, [키워드] absence All participant amplification communicable disease COVID-19 demonstrated determine diagnostic enrolled evaluated faster favor feedback fused gold standard identify inhibitor Innovation Interpretation invasive mechanism nasopharyngeal Nasopharyngeal swab nucleic acids participant Patient PCR PCR cycle PCR testing pilot study polymerase chain positive producing real-time reverse transcriptase receiving respiratory respiratory pathogen respiratory virus Result resulting RNase P RNAseP RT-qPCR Self-collection respiratory pathogen device. specimen study participant TaqPath tested threshold [DOI] 10.1016/j.ajem.2022.08.047 PMC 바로가기
A Closed-Loop Approach to Fight Coronavirus: Early Detection and Subsequent TreatmentArticle Published on 2022-10-202022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosensing caused Complication coronavirus COVID-19 COVID-19 pandemic Critical detection Diagnosis early diagnosis effective electrical Epidemic epidemic control Health helping include Infection invasive manuscript MONITOR neurostimulation patients photoacoustic imaging reducing respiration monitor. SARS-CoV-2 Severe patient Ventilation ventilator [DOI] 10.3390/bios12100900 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors receptors. regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Saliva for molecular detection of SARS-CoV-2 in pre-school and school-age childrenArticle Published on 2022-10-012022-11-15 Journal: Environmental microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Adults age asymptomatic subjects children collected comparable contrary coronavirus disease COVID-19 detection rate Diagnosis early stage independent Infection initial initial symptom invasive less management molecular nasopharyngeal NPs Numerous Patient performance RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 detection sensitivity serological seronegative significantly significantly lower Symptoms [DOI] 10.1111/1462-2920.16151 PMC 바로가기
Constrictive pericarditis following inactivated virus COVID-19 vaccine: a case report with review of the literatureCase report Published on 2022-10-012022-10-05 Journal: Radiology Case Reports [Category] 진단, [키워드] accelerate adverse effect BBIBP-CorV (Vero Cells) cardiac Case report catheterization chest CT scan Constrictive pericarditis corticosteroid therapy Course COVID-19 COVID-19 vaccine Diagnosis diagnostic diagnostic investigation diagnostic test dose etiology exclusion favor heart failure immunization inactivated Inactivated vaccine Inflammation invasive lack male mRNA COVID-19 vaccines myocarditis Patient physician provoke receiving reported SARS-CoV-2 Symptom the patient virus was performed [DOI] 10.1016/j.radcr.2022.07.021 [Article Type] Case report
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variantsArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] administration antibodies Antibody therapeutics Antiviral antiviral prophylaxis and therapeutics Biological sciences comparable conserved effective epitope fusion protein IgA IgG Fc Immunity infected with SARS-CoV-2 Infection intranasal invasive K18-ACE2 less Lineage mammalian Microbiology mucosal nanobody neutralization neutralization. neutralize omicron Pichia pastoris produced Prophylactic Prophylaxis provide RBD recognize SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe respiratory disease Therapeutic treatment transgenic mice variant variants VoC [DOI] 10.3389/fimmu.2022.995412 PMC 바로가기
Effects of intravesical BCG maintenance therapy duration on recurrence rate in high-risk non-muscle invasive bladder cancer (NMIBC): Systematic review and network meta-analysis according to EAU COVID-19 recommendationsArticle Published on 2022-09-082022-11-16 Journal: PLoS ONE [Category] meta-analysis, [키워드] appear Bayesian BCG Bladder cancer can be used chain conducted coronavirus disease Course COVID-19 COVID-19 pandemic demonstrated Effect effective European forest plot group groups highest intravesical invasive item Markov material Network meta-analysis no difference pandemic Patient receiving recommendation recommendations Reporting review systematic review therapy Treatment Urology was performed [DOI] 10.1371/journal.pone.0273733 PMC 바로가기
Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trialArticle Published on 2022-09-072022-10-06 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] 1:1 95% CI Acute kidney injury acute respiratory distress addition all-cause mortality all-cause mortality rate Analysis antibody assigned Belgium Block randomisation Brazil C5a Critically ill defined determine died dose double-blind eligible excluded France Germany hazard ratio hospital hospital discharge IMPROVE intravenously intubation invasive Invasive mechanical ventilation ITT analysis Kaplan-Meier analysis matching placebo mechanically ventilated patient monoclonal antibody Mortality multicentre Netherlands Older one patient outcome PaO participant Patient patient population phase 2 trial phase 3 trial Placebo placebo-controlled Pneumonia primary analysis Primary outcome random assignment randomised Randomly receive receiving reduced Registered reported Research Russia Safe Safety analysis safety analysis SARS-COV-2 infection Septic shock shown significant decrease significantly South Africa Standard of care survival TEAE the placebo group therapy Treatment treatment-emergent adverse event variant vilobelimab viral infections was performed with COVID-19 [DOI] 10.1016/S2213-2600(22)00297-1 PMC 바로가기 [Article Type] Article
Predictive Factors of Extubation Failure in COVID-19 Mechanically Ventilated PatientsObservational Study Published on 2022-09-012022-10-04 Journal: Journal of Intensive Care Medicine [Category] 임상, [키워드] 48 hour 95% CI Admission age Analysis APACHE II score association average Characteristics COVID-19 COVID-19 patient dialysis evaluate evaluated extubation Factor failure ICU increased the risk independent predictor intensive care invasive investigated male mechanical ventilation need for dialysis non-COVID-19 patient Non-COVID-19 patients on mechanical ventilation outcome PaO2/FiO2 ratio parameter Patient Poisson regression model predicted Predictive Predictive Factors predictor Primary outcome Probability progressed retrospective risk Sex single-center statistical analysis Symptom Symptoms the mean the patient was done was performed weaning. with COVID-19 [DOI] 10.1177/08850666221093946 PMC 바로가기 [Article Type] Observational Study